Class: Antibacterials: Aminoglycoside (Anti-infectives)
Mechanism of Action:
Molecular Formulae: C21H43N5O7 = 477.6
Precautions: Hypersensitivity to aminoglycosides. pregnancy and lactation. myasthenia gravis. caution in renal impairment and in concomitant use with nephrotoxic drugs.
Indications/Uses: Severe infections due to aerobic gram-negative bacilli. im or iv 1-1.7mg/kg tid.
Interactions: Increased risk of nephrotoxicity with cephalosporins, potent diuretics, ciclosporin.
Side Effects: Ototoxicity. nephrotoxicity. vestibular damage. neuromuscular blockade and respiratory paralysis.