Class: Misc. Agents (Misc. drugs)
Mechanism of Action:
Synonym: Folinic Acid
Molecular Formulae: C20H23N7O7 = 473.44
Precautions: Pernicious anemia and other megaloblastic anemias secondary to the lack of vitamin b12
Indications/Uses: Diminish toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists.
Interactions: Folic acid in large amounts may counteract the antiepileptic effect of phenobarbital, phenytoin and primidone, and increase the frequency of seizures in susceptible children.
Side Effects: Allergic sensitization, including anaphylactoid reactions and urticaria,