Class: H-2 Receptor Antagonists (Gastrointestinal drugs)
Mechanism of Action:
Molecular Formulae: C10H16N6S = 252.3
Precautions: Hypersensitivity. pregnancy/lactation. reduce dose in renal or hepatic insufficiency.
Indications/Uses: Peptic ulcer disease 800mg daily. zollinger-ellison syndrome, reflux oesophagitis 800-1600mg daily.
Interactions: Increase activity of drugs metabolized by hepatic cytochrome p450; phenytoin, theophylline, oral anticoagulants, diazepam, propranolol.
Side Effects: Headache. dizziness. reversible gynaecomastia and confusional states. gastro-intestinal disturbances. altered liver function tests. alopecia.rarely tachycardia.