Allopurinol 300mg Tabs 28’s
KSh 360.00
Allopurinol 300mg Tablets are used to address ailments associated with high levels of uric acid in the body, such as gout, certain types of kidney stones, and some enzyme disorders. It works by reducing the production of uric acid, thereby preventing urate crystal formation and its associated complications. Active Substance: Allopurinol 300mg per tablet.
Xanthine Oxidase Inhibitors
Suggested Use
Allopurinol is used to treat:
- Gout: Reduces uric acid levels to prevent gout attacks.
- Kidney Stones: Prevents the formation of uric acid stones.
- Certain Enzyme Disorders: Helps manage conditions like Lesch-Nyhan syndrome.
- Cancer Treatment: Prevents uric acid nephropathy during chemotherapy.
Dosage:
The typical dosage for adults is:
- Mild conditions: 100-200 mg daily.
- Moderate conditions: 300-600 mg daily.
- Severe conditions: Up to 900 mg daily. It’s important to start with a low dose and gradually increase it to minimize side effects.
Warning
Hypersensitivity Reactions: Discontinue immediately if symptoms such as rash, fever, or other allergic reactions occur. Severe reactions like Stevens-Johnson syndrome and toxic epidermal necrolysis are rare but possible.
- Kidney Function: Use cautiously in patients with impaired renal function; dose adjustments are necessary.
- Hepatic Function: Monitor liver enzymes during prolonged use, especially in patients with pre-existing liver conditions.
- Initial Gout Flares: May provoke acute gout flares at the start of treatment; consider prophylactic use of NSAIDs or colchicine.
- Hydration: Maintain adequate hydration to reduce the risk of kidney stones and enhance uric acid excretion.
- Drug Interactions:
- May interact with azathioprine, mercaptopurine, and cyclophosphamide, requiring dose adjustments.
- Increased risk of skin reactions when used with ampicillin/amoxicillin.
- Potentiation of anticoagulants like warfarin is possible; monitor INR.
- Pregnancy and Lactation: Use only if the potential benefit outweighs the risk; consult a healthcare provider.
- Alcohol: Limit alcohol intake as it can increase uric acid levels and reduce treatment efficacy.